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Sometimes the firewall is blocking the traffic to the SAP System. This could be a local Firewall, but also a Firewall in the destination network.
You can use the tool paping.exe to ping the port and to check if the Firewall is open.
The syntax to use paping.exe is:
paping.exe SAPServer -p port -c 3
SAPServer is your SAPsystem you want to ping. If a SAP-Router is used, the ports are 3299 and 3399. If not, the ports are 32XX and 33XX. XX is usually the system number (like 00, or 05).
paping.exe 192.168.0.9 -p 3305 -c 3
Some important Portnumbers:
sapdp00 3200/tcp # SAP Dispatcher. 3200 + Instance-Number
sapgw00 3300/tcp # SAP Gateway. 3300 + Instance-Number
sapsp00 3400/tcp # 3400 + Instance-Number
sapms00 3500/tcp # 3500 + Instance-Number
sapmsSID 3600/tcp # SAP Message Server. 3600 + Instance-Number
sapgw00s 4800/tcp # SAP Secure Gateway 4800 + Instance-Number